How to handle Guidelines that are mentioned as 'Required' in 2012

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Hello,
I am using MISRA 2012 to review the SW code(Both Auto code and Manual). 
I am bit confused to handle the the guidelines that are mentioned as 'Required'. 
I would like to know what are all the cases when the the rules can be deviated with reasonable justification. And what are all the cases when deviation is not at all accepted with any justification. 

Thank you!

[misra-c]

A *required* guideline may be deviated if required, with suitable justification, and subject to appropriate approval.

It is not permitted to violate a *mandatory* guideline, even with a deviation.